I've lost one due to a job loss and another because he's a mortgage advisor.
But there's no one single 'big employer' round here; so I guess we're lucky.
I'm guessing that if you live in an area with, say for example a car manufacturing plant, that employs thousands of 'locals'; and that firm goes bust or cuts everyone's wages/hours; and you have a lot of customers from that factory, then you could lose a few. Not to mention the other jobs that are off-shoots; relying on that big company's trade.
However, from the little I understand, the last big reccesion in the 1980s really hit the blue collar workers. But this one is different because it's hitting the white-collar workers in the South-East due to the subsequent growth from the 1980s into the financial sector.
I could be wrong though, I'm just a window cleaner; and a Geordie one at that.