I used to think bolting in the tank was by far the safest way, but i'm not so sure these days. The reason for this has to do with how car safety has progressed since I first started driving. Back then it was generally recognised that a big strong car, or an old school 4x4 with a separate chassis would be the best. Of course what actually happened was that due to the strength and rigidity of the car or 4x4 in question, all the forces of the impact was transferred directly to the passenger, resulting in very serious whiplash injuries, which could take a lot longer to recover from than a broken leg or two. Modern cars are designed to crumple, absorb the impact and dissipate the energy around the passenger compartment. So with your tank being bolted rigidly into the back of your van, with absolutely no give, what is going to happen to all that energy (bearing in mind, in my case, that is half a ton of water) if you have a crash?. I suspect, for my van, the bolts will simply shear off with potentially fatal consequences. If the tank is strapped in though, provided it has been done properly, there is going to be some give as the straps stretch under the force, before doing what they are designed to do, and restraining the tank. Also, a plastic tank will deform (possibly burst if you are lucky) under the weight of water, which will, again, help to release the energy.
I must stress however, this is just my opinion, and in no way scientific or proven fact!, but, because of this, I will give very serious consideration to strapping in the tank for my next van.