I normally set my pressure setting to the minimum required to run the pump without cycling on and off. Ie. with the flow valve fully open on my pole hose and a flow that I'm happy with I want the pump running constantly and not cutting in and out. Turn the flow valve off and the pump should stop after one or two short cycles.
Too much pressure and you run the risk of bursting hoses, blowing connectors and even damaging di vessels. Once you have the pressure setting correct then you can play with the flow rate without any further problems.
One thing I've never been able to figure out is why it can take so long to fire up the pump when the pole valve is opened initially

Starts pretty quick mind, when I slide the pole back in the rack and accidentally knock the valve open :
