Most RO membranes perform better after they have been running for a bit, also its not good for them to have high pressure shoved into them in one go. With that in mind i generally start mine on flush for 10 mins and then close up to production level. I will very often flush for 10-15 mins after i finish production too. Flushing is the only thing that can preserve your RO from fouling so its important to do it often.