Mick, I use 10 inch carbon and sediment filters on my 40 inch r/o.
Boosted with a b and q water tranfer pump. Produces 1000ltr in 4 hours.
Yes you will need to flush before running it through your di. I flush a 18 gallon buckets worth.
As regards running without the carbon block, I am not the best at replacing my pre filters and indeed bought my system second hand and used there old pre filters for a year before changing.
I have experienced NO problems with the R/o unit. The 40 inch is over 6 years old and filters down from 180 ish to 011.
Hope this helps.