Dave, is it a Merlin you are using? If so it would account for the high readings, if not then it could be a dodgy membrane or two. The readings are very high, and the membranes should last for years.
I take it you have a good flow coming from your waste?
The higher reading coming out the RO is associated with the membranes being on the way out and not the prefilters. The prefilters are usually monitored with the pressure gauge, a drop in pressure = change the prefilters.
Peter